“depletion of macrophages with anti-CSF1R significantly reduced the anti-tumor efficacy of Ab1V209” 中的 “AblV209” 应改为 “Ab1V209”，以保持一致性。
“therapeutic efficacy of Ab1V209 was observed” 可以改为 “therapeutic efficacy of Ab1V209 was evaluated”，以使表述更清晰。
以下是经过修改的版本：
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To examine whether Ab1V209 is effective against cancer, MC38 tumor-bearing mice were treated with PBS, 1V209, and Ab1V209 four times on days 6, 8, 10, and 12 (Figure 6a). On day 14, the modulation of anti-tumor immune responses within the TME triggered by Ab1V209 was investigated. In the TME of Ab1V209-treated mice, the expression of co-stimulatory molecules such as CD80 and CD86 on F4/80+ CD11b+ TAMs, and the frequency of CD3+CD8+ T cells was increased (Figure 6b, 6c, and 6d). Moreover, synergistic IL-6 and TNF-α production was observed from peripheral blood of mice treated with Ab1V209 (Supplementary Figure 17). Next, the therapeutic efficacy of Ab1V209 was evaluated. The growth of MC38 subcutaneous tumors following Ab1V209 treatments was effectively suppressed, while depletion of macrophages with anti-CSF1R significantly reduced the anti-tumor efficacy of Ab1V209 (Figure 6e and 6f). Furthermore, no significant weight loss was observed after multiple Ab1V209 treatments (Supplementary Figure 18). Although tumors continued to grow, Ab1V209 significantly prolonged overall survival (Figure 6g). These results suggested that Ab1V209 activated anti-tumor immunity of TAMs.
